Structure containing fluid on a tendon sheath or joint capsule, and forming a small, round knob under the skin the size of a pea or marble. Usually found on the back of the hand, the wrists, the ankles or behind the knee, ganglia are not painful, but can hinder movement. The fluid contained is bright to light red and watery. A ganglion is formed by tissue degeneration of the tendon sheath or joint capsule as a result of irritation of this tissue, for example during or after tenosynovitis, or in rheumatic conditions of the joints. They often occur without clear cause. A ganglion may be burst by pressure, but it will recur after a few months. Also the fluid may be sucked out with a hypodermic syringe and corticosteroids injected into the cavity, but again the ganglion will recur in time. The best therapy is removal of the ganglion and surrounding tissue by surgery.

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