Piperazine along with mebendazole are the two most frequendy used antihelminthic drugs. Although there is a myriad of herbal treatments that have been used for centuries in dealing with infestation by worms such as roundworms and threadworms, these two drugs are safe and effective. I recommend the use of these drugs because they are poorly, if at all, absorbed into the system and stay in the bowel, killing the parasites. Very few people have any side effects or problems.