Serious, potentially fatal deficiency in urine production resulting from extensive tissue damage caused by serious injury or severe burns. Another possible cause is excessively long interruption of blood supply to one or both legs, particularly if a tourniquet is applied to stop arterial bleeding, a procedure that can cause tissue death. Serious crushing or death of part of the body causes massive internal bleeding and circulatory failure, which can be fatal. The damaged tissue produces large quantities of protein, especially muscle protein, which is transported by the blood to the kidneys, damaging them and reducing urine production. Finally production of urine can stop completely, and breakdown products accumulate in the blood, which can lead to death.