Manifestation closely associated with hives or urticaria. Hives is an itchy red skin eruption with swelling of the skin caused by local dilation of the blood vessels. This can be caused by: anaphylaxis, usually associated with food or medication, infectious diseases (for example glandular fever), low temperature, emotional tension, malignant diseases (e.g. Hodgkin’s disease) or diseases of the tissue (e.g. lupus erythematosus). If such dilation lies deeper than the skin then the condition is known as angioneurotic oedema. Resultant swelling in the intestine can cause nausea and vomiting; painful, stiff joints; and shortness of breath through obstruction of the air passages. The condition usually clears up spontaneously within a few days. Medication is necessary when the location of the oedema could lead to serious complications – for example in the joints and air passages.